Dyslipidemia Information
Dyslipidemia is an abnormal amount of lipids (e.g. cholesterol and/or fat) in the blood. In developed countries, most dyslipidemias are hyperlipidemias; that is, an elevation of lipids in the blood, often due to diet and lifestyle. The prolonged elevation of insulin levels can lead to dyslipidemia. Increased levels of O-GlcNAc transferase (OGT) are known to cause dyslipidaemia.[1]
Not to be confused with lipedema.
Classification
There are two major ways in which dyslipidemias are classified:
- Phenotype, or the presentation in the body (including the specific type of lipid that is increased)
- Etiology, or the reason for the condition (genetic, or secondary to another condition.) This classification can be problematic, because most conditions involve the intersection of genetics and lifestyle issues. However, there are a few well defined genetic conditions that are usually easy to identify.
Fredrickson Classification:[1]
For more a detailed version, see
Hyperlipidemia#Classification.
| Phenotype |
I |
IIa |
IIb |
III |
IV |
V |
| Elevated Lipoprotein |
Chylomicron |
LDL |
LDL and VLDL |
IDL |
Triglycerides |
VLDL and chylomicrons |
Types
References
- ^ Fredrickson DS, Lees RS. A system for phenotyping hyperlipoproteinemia. Circulation 1965;31:321-327.
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Inborn error of lipid metabolism: dyslipidemia (E78, 272.0–272.6) |
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| Hyperlipidemia |
Hypercholesterolemia/Hypertriglyceridemia (Type I, Familial hypercholesterolemia/Type IIa, Combined hyperlipidemia/Type IIb) · Xanthoma/Xanthomatosis
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| Hypolipoproteinemia |
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| Lipodystrophy |
Barraquer–Simons syndrome
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| Other |
Lipomatosis · Adiposis dolorosa · Lipoid proteinosis · APOA1 familial renal amyloidosis
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