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Dyslipidemia Information

Dyslipidemia is an abnormal amount of lipids (e.g. cholesterol and/or fat) in the blood. In developed countries, most dyslipidemias are hyperlipidemias; that is, an elevation of lipids in the blood, often due to diet and lifestyle. The prolonged elevation of insulin levels can lead to dyslipidemia. Increased levels of O-GlcNAc transferase (OGT) are known to cause dyslipidaemia.[1]

Not to be confused with lipedema.

Classification

There are two major ways in which dyslipidemias are classified:

Fredrickson Classification:[1]

For more a detailed version, see Hyperlipidemia#Classification.
Phenotype I IIa IIb III IV V
Elevated Lipoprotein Chylomicron LDL LDL and VLDL IDL Triglycerides VLDL and chylomicrons

Types

Increases Decreases
Lipid
Lipoprotein
Both

References

  1. ^ Fredrickson DS, Lees RS. A system for phenotyping hyperlipoproteinemia. Circulation 1965;31:321-327.
· · Inborn error of lipid metabolism: dyslipidemia (E78, 272.0–272.6)
Hyperlipidemia Hypercholesterolemia/Hypertriglyceridemia (Type I, Familial hypercholesterolemia/Type IIa, Combined hyperlipidemia/Type IIb) · Xanthoma/Xanthomatosis
Hypolipoproteinemia
Hypoalphalipoproteinemia/HDL Lecithin cholesterol acyltransferase deficiency · Tangier disease
Hypobetalipoproteinemia/LDL Abetalipoproteinemia · Apolipoprotein B deficiency
Lipodystrophy Barraquer–Simons syndrome
Other Lipomatosis · Adiposis dolorosa · Lipoid proteinosis · APOA1 familial renal amyloidosis

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